10/30/2022 0 Comments Foolproof xrd software free download![]() In addition to polymorphs, hydrates, solvates, salts, and co-crystals are other various solid forms of an API, which are frequently explored for drug development. The classical methods include sublimation ( 4), crystallization from a single solvent ( 5), evaporation of a binary mixture of solvents ( 6), vapor diffusion ( 7), thermal treatment( 8), crystallization from the melt ( 9), desolvation of crystalline solvents ( 10), antisolvent addition, grinding ( 11), and vapor-induced transformations ( 12). Polymorphs of a compound may be prepared by various methods ( 3). In recent years, there has been an increased regulatory interest to characterize and to control the physical form of active pharmaceutical ingredients in dosage forms ( 2). These transitions occur depending upon the thermodynamic and kinetic stability of the forms. Solid-phase transitions may occur during various processing steps involved in the preparation of active pharmaceutical ingredient (APIs for example purification, crystallization, extraction, etc.), during formulation ( i.e., milling, granulation, drying and compaction) and also upon storage. Polymorphic changes can significantly alter the physicochemical properties such as solubility, dissolution rate, flowability, compressibility, stability, and also the bioavailability ( 1) of the compounds. Due to its increasing importance, both innovator and generic pharmaceutical companies are actively pursuing the polymorphic screening of drug substances. Polymorphic screening of active ingredients has attracted much recent attention in the pharmaceutical and agrochemical industry. ![]()
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